By F.J. Dixon, Henry G. Kunkel (Eds.)
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Additional info for Advances in Immunology, Vol. 20
The inheritance of idiotypy is now clearly established in the rabbit and the mouse. This phenomenon has profound implications for any hypothesis purporting to explain the origin of antibody diversity, and, although alternative explanations are possible, it is one of the strongest current arguments supporting a pure germ-line theory. The most detailed view of the molecular orientation of the immunoglobulin V region, which is consistent with the known serological and immunochemical data, has been, and is being, obtained by X-ray diffraction analyses.
Med. 132, 951. Briles, D. , and Krause, R. M. (1972). J . Immunol. 109, 1311. Capra, J. D. ( 1971 ). Nature (London) New Biol. 230, 61. Capra, J. , and Hurvitz, A. (1970). J . Immunol. 105, 949. Capra, J. , and Kehoe, J. M. (1974a). Proc. Nut. Acud. Sci. U. S. 71, 845. Capra, J. , and Kehoe, J. M. ( 1974b). Proc. Nut. Acad. Sci. S . (in press). Capra, J. , and Kunkel, H. G. (1970). Proc. Nut. Acad. Sci. U. S . 67, 87. Capra, J. , Kehoe, J. , Winchester, R. , and Kunkel, H. G. (1971). Ann. N. Y.
Goetzl and Metzger (1970) localized an affinity label close to the first light-chain hypervariable region of a murine myeloma protein that possesses anti-DNP activity. FranEk localized an affinity label to tyrosine 33 of the porcine light chain, and to a lesser extent, tyrosine 93 of the light chain ( FranGk, 1971). Before discussing the affinity labeling of the heavy chain, two new advances in the field of affinity labeling reagents should be mentioned. First, the synthesis of the bromacetyl derivatives of the dinitrophenyl hapten has the advantage that the length of the side chain between the hapten and the reactive group can be varied.
Advances in Immunology, Vol. 20 by F.J. Dixon, Henry G. Kunkel (Eds.)