By Mieczyslaw Pokorski
Respiratory allergic reaction is continually encountered and is sharply at the upward thrust, fairly within the so much weak age-groups: little ones and seniors. hypersensitive reaction leads to airway hyperactivity and elevated airway resistance, with all inflammatory sequelae being ensued. The chapters convey how breathing allergic reaction study is interconnected with different disciplines by means of discussing neurotransmitter, membrane receptor, and ionic channel mechanisms of allergic reaction and through giving diagnostic and pharmacological cues on desensitization and therapy.
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Additional info for Allergens and Airway Hyperreactivity
2). 2 Contractile Response of Airway Smooth Muscles In Vitro In vitro tests of contractility of tracheal and pulmonary strips in response to cumulative doses of acetylcholine and histamine after the 14-day treatment with pinacidil and NS1619 gave similar results to those after acute Fig. 1 Changes in specific airway resistance (sRaw) in vivo in response to OVA sensitization and then after long-term treatment with pinacidil and NS1619. 001 vs. 05 vs. OVA 40 M. Kocmalova et al. Table 1 Effects of acute and long-term treatment with K+ channels openers on tracheal and pulmonary tissue contractility Fig.
Medvedova, M. Joskova, S. Franova, and M. Sutovska Abstract High-conductive calcium-sensitive potassium channels (BK+Ca) and ATP-sensitive potassium (K+ATP) channels play a significant role in the airway smooth muscle cell and goblet cell function, and cytokine production. The present study evaluated the therapeutic potential of BK+Ca and K+ATP openers, NS 1619 and pinacidil, respectively, in an experimental model of allergic inflammation. Airway allergic inflammation was induced with ovalbumine in guinea pigs during 21 days, which was followed by a 14-day treatment with BK+Ca and K+ATP openers.
Incubation, contractile responses were measured after application of cumulative doses of acetylcholine or histamine (10À8–10À3 mol). 5 Measurement of Cilia Beating Frequency Biological specimens were collected after transversal section of the spinal cord. Tracheal epithelium was obtained by a ‘brushing method’ through a tracheotomic opening. The epithelial scraping was put into a drop of saline of 37 C. Intact cilia were detected under light microscopy associated with high-speed camera (Basler 504KC; Adept Turnkey Pty Ltd, Brookvale, Australia).
Allergens and Airway Hyperreactivity by Mieczyslaw Pokorski