Get Antiparasitic and antibacterial drug discovery: from PDF

By Paul M. Selzer

ISBN-10: 1282118463

ISBN-13: 9781282118461

ISBN-10: 3527323279

ISBN-13: 9783527323272

ISBN-10: 3527626816

ISBN-13: 9783527626816

Addressing parasitic illnesses and people because of micro organism, this a lot wanted reference and guide offers a different perception into the process followed via advertisement technology in the direction of infectious ailments, together with the paintings of medicinal chemists. the various authors are scientists with hands-on event of drug discovery devices in the pharmaceutical undefined. furthermore, the textual content covers efforts in the direction of drug improvement in infectious illnesses from educational teams and non revenue corporations

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Quinolone lead compounds with antimalarial 23 24 1 Discovery the Mechanism of Action activity targeting the bacterial-like type II NADH:ubiquinone oxidoreductase were also found to affect cytochrome b/c [175]. At various times after drug addition, 35 key metabolites were monitored by LC-MS and the disruption of pyrimidine metabolism was confirmed: accumulation of dihydroorotate and a reduction of downstream intermediates [175]. Similarly, fosmidomycin was thought to target Plasmodium deoxyxylulose 5-phosphate reductoisomerase, an enzyme involved in the production of isoprenoids [176, 177].

The changes in protein quality control are consistent with genomic analyses, which found that mutations in the P. falciparum Kelch-13 propeller correlated with artemisinin resistance [104]. A search for inhibitors of Plasmodium phosphatidylinositol-3-kinase revealed that artemisinin is a potent inhibitor of enzyme activity, preventing formation of phosphatidylinositol-3-phophate [105]. In ring stages, a range of secreted proteins is modified by phosphatidylinositol-3-phophate, resulting in their retention in the endoplasmic reticulum; polyubiquitination and Kelch-13 binding result in degradation of phosphatidylinositol-3-kinase [105].

So far, however, most gene expression results relevant to parasite chemotherapy are from comparisons between drug-resistant and drug-sensitive cells: in this case, differences in expression levels or pattern can reflect either gene regulation or changes in gene copy number. Candidate Genes Before high-throughput methods were available, a “candidate gene” approach was adopted. For example, the expression of genes previously known to be involved in drug resistance could be checked in drug-resistant lines [97].

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Antiparasitic and antibacterial drug discovery: from molecular targets to drug candidates by Paul M. Selzer


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